Owen John Llewellyn Rackham

Dr Owen Rackham is an expert in the development of computational approaches for cell reprogramming and disease-gene association.

His primary research interest is in understanding how genes and drugs can coordinate changes in cellular phenotypes and use this to treat disease or initiate transdifferentiation
His group works on ways to identify key regulators that can control cell fate in order to find novel routes for cell conversion, as well as identifying drug targets to develop new cell therapies and pharmacological treatments for human disease.

Education

Ph.D, Computational Biology (2013)
MRes, Complexity Sciences, University of Bristol (2012)
MSc, Natural Computation, University of Birmingham (2007)
BSc, Computer Science, University of Exeter (2005)

Areas of Expertise

Analysis of high-throughput sequencing data
Biological network analysis
Statistics

Selected publications

[1] Chung-Chau Hon, Jordan A Ramilowski, Jayson Harshbarger, Nicolas Bertin, Owen JL Rackham et al. An atlas of human long non-coding RNAs with accurate 5′ ends, Nature, 543:7644 199-204, 2017 JIF: 38

[2] Owen JL Rackham, Sarah R Langley, Thomas Oates, Eleni Vradi, Nathan Harmston, Prashant K Srivastava, Jacques Behmoaras, Petros Dellaportas, Leonardo Bottolo, Enrico Petretto. A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation, Genetics, 205:4 1443-1458, 2017 JIF: 6

[3] Kamaraj, Uma S; Gough, Julian; Polo, Jose M; Petretto, Enrico; OJL Rackham. Computational methods for direct cell conversion, Cell Cycle,1-12,2016,Taylor & Francis JIF: 4

[4] Marina Lizio, Jayson Harshbarger, Imad Abugessaisa, Shuei Noguchi, Atsushi Kondo, Jessica Severin, Chris Mungall, David Arenillas, Anthony Mathelier, Yulia A Medvedeva, Andreas Lennartsson, Finn Drabløs, Jordan A Ramilowski, OJL Rackham, Julian Gough, Robin Andersson, Albin Sandelin, Hans Ienasescu, Hiromasa Ono, Hidemasa Bono, Yoshihide Hayashizaki, Piero Carninci, Alistair RR Forrest, Takeya Kasukawa, Hideya Kawaji Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals, Nucleic Acids Research,45,D1,D737-D743,2017,Oxford University Press JIF: 9

[5] Schafer, Sebastian; de Marvao, Antonio; Adami, Eleonora; Fiedler, Lorna R; Ng, Benjamin; Khin, Ester; OJL Rackham; van Heesch, Sebastiaan; Pua, Chee J; Kui, Miao; Titin-truncating variants affect heart function in disease cohorts and the general population, Nature Genetics,49,1,46-53,2017 JIF: 29