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 (Professor Dr.) Mahiran Basri
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(Professor Dr.) Mahiran Basri

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English, Malay

Areas of expertise:
Biocatalysis, Fats and Oil Chemistry, Enzyme Technology

Mahiran Basri was born in Muar, Johor, Malaysia on the 12th Nov. 1957. She had her early education in Muar and continued her secondary education at Kolej Tunku Kurshiah, Seremban, Negeri Sembilan, Malaysia. She completed her Malaysian Certificate, Examination in 1975 and pursued her higher studies at Northern Illinois University, USA. She obtained her B.S. degree in Chemistry in 1980 and the M.S. degree also in Chemistry in 1982 from the same university. After returning to Malaysia in the same year, she was employed by the Chemistry Department of Malaysia, Petaling Jaya as a chemist and was attached to the Forensic Department.

She joined the Department of Chemistry, Universiti Putra Malaysia in Dec. 1982 as a lecturer. She obtained her Ph.D. degree in Chemistry in 1993 from Universiti Putra Malaysia. She did research attachments at Kyoto University, Japan and Lund University, Sweden. She has been a pioneer member of the Enzyme Technology Research group in the Faculty. Subsequently, she has developed a very active Biocatalysis research group at the Department of Chemistry. She is solely responsible for the setting up and development of the Bioorganic synthesis lab at the Department whereby, the work carried out in the lab consists of interdisciplinary research in the areas of chemistry, biochemistry and microbiology.

Her main research work is on organic synthesis using enzymes. One aspect of the work is in the designing of enzymes so that they acquire enhanced properties such as organic solvent tolerant and thermostable for use in organic synthesis. Another aspect is in the use of these enzymes as catalysts to produce valuable products such as in the production of various palm oil based esters and amides, liquid wax esters, medium chain glycerides and fish oil esters. She is also actively working in the synthesis of optically active compounds which has many uses in the drugs and pharmaceutical industries, and in the synthesis of a more active betulinic acid derivatives, an anti-HIV compounds.

Her latest interest is in the formulation of these compounds in the cosmetics and pharmaceuticals. Her other interest is in insilico designing of enzymes through molecular modeling and dynamics. She was the recipient of research grants from Third World Academy of Science (TWAS), Malaysia Toray Science Foundation (MTSF) and IRPA, SAGA, Sciencefund, FRGS, RUGS, NBD and CRDF funds. Her latest research grant is to work on the production of nanodelivery system for cosmetics and pharmaceuticals and Large-Scale Production of palm-based wax esters. Her work has been published extensively in various international and national journals.

She has won awards such as the Archer Daniels Midland Award from the American Oil Chemists’ Society, the Tan Sri Ong Kee Hui Award and UPM Best Researcher Award, Ram Rais Biotechnology Award and Gold Medal at International Invention, Innovation, Industrial Design & Technology Exhibition (I-TEX) 2004, A Gold and silver medals at Geneva-Palexpo International Exhibition of Inventions, New Techniques and Products 2005. She has been invited to write articles as chapters in several books such as Methods in Biotechnology, Biocatalysts in Non-conventional Media and Recent Developments in Oil Chemistry. Students under her supervision have also won awards in their respective research work. Her research group has published 3 books. Her research work has been filed for patents in Malaysia as well as in the United States, Indonesia and Singapore.

1) Leow, T. C., Rahman, R. N. Z. R. A., Basri, M., and Salleh, A. B. (2007). High Temperature Crystallization of Thermostable T1 Lipase. Crystal Growth & Design. 7: 406-410 (IF 3.551)

2) Leow, T. C, Rahman, R. N. Z. R. A., Salleh, A. B., and Basri, M. (2007). A Thermoalkalophilic Lipase of Geobacillus sp. T1. Extremophiles. 11: 527-535 (IF 2.125)

3) Rahman, R. N. Z. R. A., Muhamad, S., Salleh, A. B., and Basri, M. (2007). A New Organic Solvent Tolerant Protease from Bacillus pumilus 115b. Journal of Industrial Microbiology and Biotechnology. 34: 509–517 (IF 1.416)

4) Shariff, F. M., Leow, T. C., Mukred, A. D., Salleh, A. B., Basri, M., and Rahman, R. N. Z. R. A. (2007). Production of L2 lipase by Bacillus sp. strain L2: nutritional and physical factors. Journal of Basic Microbiology. 47: 406-412 (IF 1.0)

5) Rahman, R. N. Z. R. A., Leow, T. C., Salleh, A. B., and Basri, M. (2007). Geobacillus zalihae T1, a novel thermophilic lipolytic bacterium isolated from palm oil mill effluent in Malaysia. BMC Microbiology BMC Microbiology, 7:77 - (IF 2.9)

6) Basri, M., Rahman, R. N. Z. R. A., Ebrahimpour, A., Salleh, A. B., Gunawan, E. R., and Rahman, M, B. A. (2007). Comparison of estimation capabilities of response surface methodology (RSM) with artificial neural network (ANN) in lipase-catalyzed synthesis of palm-based wax ester. BMC Biotechnology. BMC Biotechnology 2007, 7:53 (IF 2.74)

7) Othman, S. S., Basri, M., Hussein, M. Z., Rahman, M. B. A., Jasmani, H., Rahman, R. N. Z. R. A., and Salleh, A. B. (2008). Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports. Food Chemistry.106 (437–443– ISSN 0308-8146; (IF 1.811)

8) Rahman, M. B. A., Jaafar, A. H., Basri, M., Rahman, R. N. Z. R. A., Salleh, A. B., and Wahab, H. A. Design of novel semisynthetic metalloenzyme from thermolysin”, BMC Systems Biology 2007, 1 (Suppl 1):P68 (8 May 2007). ISSN 1752-0509.

9) Rahman, M. B. A., Zaidan, U. S., Basri, M., Salleh, A. B., Rahman, R. N. Z. R. A., and Hussein, M. Z. Enzymatic synthesis of methyl adipate ester using lipase from Candida rugosa immobilised on Mg, Zn and Ni of layered double hydroxides (LDHs), Journal of Molecular Catalysis B : Enzymatic (accepted after correction August 2007) – ISSN 1381-1177; (IF 1.685)

10) Matsumura, H., Yamamoto, T., Leow, T. C., Salleh, A. B., Basri, M., Inoue, T., Kai, Y., and Rahman, R. N. Z. R. A. (2007). Novel cation- interaction revealed by crystal structure of thermoalkalophilic lipase, PROTEINS: Structure, Function, and Bioinformatics. (IF 4.684)

11) Mat Radzi, S., Basri, M., Salleh, A. B., Ariff, A., Mohammad, R. Abdul Rahman, M. B. and Abdul Rahman, R. N. Z., 2006. J. Chem. Technol. Biotechnol., 81, 374-380.

12) Basri, M., Salleh, A. B., Abdul Rahman, R. N. Z. and Abdul Rahman, M. B., 2005. Current Topics in Catalysis, 4, 23-41.

13) Azmahani Sulaiman, Mahiran Basri, Abu Bakar Salleh, Raja Noor Zaliha Raja Abdul Rahman, Salmiah Ahmad (2005) Phase behavior of oleyl oleate with non-ionic Surfactants. J. Dispers. Sci. Technol. 26:689-691.

14) Erin Ryantin Gunawan, Mahiran Basri, Mohd. Basharuddin Abd. Rahman, Abu Bakar Salleh, Raja Noor Zaliha Abd. Rahman (2005). Study on Response Surface Methodology (RSM) of lipase-catalysed synthesis of palm-based wax ester. Enz. Microbiol. Technol . 37:739-744.

15) Dedy Suhendra, Kwa Pei Yeen, Md. Jelas Haron, Sidik Silong, Mahiran Basri and Wan Md. Zin Wan Yunus (2005) Copper ion extraction by a mixture of fatty hydroxamic acids synthesized from commercial palm olein. Solvent Extraction and Ion Exchange. 23:713-723.

16) Roila Awang, Mahiran Basri, Salmiah Ahmad and Abu Bakar Salleh (2005). Thermomyces lanuginosus Lipase-catalyzed Esterification of 9, 10-Dihydroxystearic acid and Monohydric Alcohol. J. Oleo Sci. 54(5):305-309.

17) Salina Mat Radzi, Mahiran Basri, Abu Bakar Salleh, Arbakariya Ariff, Rosfarizan Mohammad, Mohd. Basyaruddin Abd Rahman, Raja Noor Zaliha Abd. Rahman (2005) Large scale production of liqud wax ester by immobilized Lipase. J Oleo Sci. 54, No. 4, 203-209

18) Abdul Rahman, M. B., Tajudin, S.M., Hussein, M. Z., Rahman, R. N. Z., Salleh, A. B. and Basri, M. (2005) Application of natural kaolin as support for the immobilization of lipase from Candida rugosa as biocatalsytfor effective esterification, App. Clay Sci., 2005, 29, 111– 116.

19) Mohd Basyaruddin Abdul Rahman, Mohd. Zobir Hussein, Raja Nor Zaliha Abdul Rahman, Abu Bakar Salleh and Mahiran Basri. (2005) Application of Advanced Materials as Support for Immobilization of Lipase from Candida Rugosa. Biocat. Biotransform.23(30):1-6.

20) Mohd Basyaruddin Abdul Rahman, Azizah Misran, Ahmad Haniff Jaafar, Habibah Abdul Wahab, Raja Nor Zaliha Abdul Rahman, Abu Bakar Salleh and Mahiran Basri. (2005) Screening and Docking of Chemical Ligands onto Pocket Cavities of Protease for Desinging a Biocatalyst. Biocat. Biotransform. 23 (3): 1-6.

*(a full list of publications will be available on request)
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