Experts database
 Dr LOURDES J. CRUZ
Name:
Dr LOURDES J. CRUZ

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Country:
Philippines

Institution:
Languages:
English

Areas of expertise:
Biodiversity, conservation & drug development; anti-TB compounds; conopeptides and other neuroactive compounds; paralytic shellfish poisons and other marine toxins; use of HPLC for quality assessment of honey; linking academe to poor rural communities; defining a socio-cultural development index for indigenous communities

Biography:
In January 2008, Dr. Lourdes J. Cruz was awarded the the Order of National Scientist by President Gloria Macapagal-Arroyo in recognition for her world class research.

Background of Dr Lourdes J. Cruz

Education
B. S. Chemistry - University of the Philippines Diliman, 1962
M. S. Biochemistry - University of Iowa, Iowa City, U.S.A., 1966
Ph.D. Biochemistry - University of Iowa, Iowa City, U.S.A., 1968

Professional Experience
1962-1963 - Research Aide, International Rice Research Institute, Philippines
1964-1968 - Graduate Assistant, University of Iowa, U.S.A.
1968-1969 - Assistant Biochemist, Intl. Rice Research Institute, Philippines
1970 (5 mo.) - Research Associate, Dept. of Biology, Kansas State Univ, U.S.A.
1970-1973 - Assistant Professor, Department of Biochemistry, College of Medicine, University of the Philippines, Manila
1973-1977 - Associate Professor, Department of Biochemistry, College of Medicine, University of the Philippines, Manila
1977-1989 - Professor, Department of Biochemistry, College of Medicine, University of the Philippines, Manila
1985-1986 - Professorial Chair in Biochemistry, UP Manila
1976-1986 - Research Associate, Department of Biology, University of Utah, U.S.A. (3-7 months a year)
1987- 2004 - Research Professor, Department of Biology, University of Utah, Salt Lake City, Utah (p.t.; retired May 2004)
1989- present - Professor, Marine Science Inst., University of the Philippines (1989-Aug 2005, part-time; Sep 2005-present, full-time)

Administrative Experience:
1980-1986 Chairperson, Department of Biochemistry & Molecular Biology, College of Medicine, University of the Philippines, Manila

Other Activities:
1996 – present - President, Center for BioMolecular Science Foundation
1999 – present - President, Bataan Center for Innovative Science and Technology
2001 – present - Implementation of Rural LINC Program among poor communities of Morong, Bataan

International Awards:
1993 - Sven Brohult Award, International Foundation for Science, Sweden
2001 - Outstanding ASEAN Scientist and Technologist Award, Brunei Darrusalam

Other Honors & Awards:
1981 - Outstanding Young Scientists Award (Chemistry), NAST
1982 - Achievement Award (Chemistry) NRCP
1986 - The Outstanding Women in the Nation's Service (Science), TOWNS Foundation and Lion's Club (Philippine Chapter)
1987 - Academician, National Academy of Science and Technology, Philippines
1991 - Professional Achievement Award in Biochemistry, UP Alumni Association
1991 - Achievement Award (Research & Research Management), Federation of Philippine Chemistry Societies
1994 - Medal of Distinction (Research), Philippine Soc. for Biochem. & Mol. Biol.
1996 - Outstanding Alumnus. UP Chemistry Alumni Foundation
2000 - Gregorio Y. Zara Award in Basic Science, Phil. Association for the Advancement of Science
2001 - Service Award, Philippine Society for Biochemistry & Molecular Biology
2002 - Gawad Chancellor Award for Research
2006 - Elected by NAST to the Order of National Scientist (Presidential Proclamation signed in November 2006; conferred by PGMA on 14 Jan 2008 )
2006 - UP Scientist III Award (3-years)
2007 - Gen Emilio Aguinaldo Outstanding Achievement (Cavite)

Professional Service
2008- present Member Editorial Board, Philippine Science Letters
2000- present Member, Editorial Board, Journal of Toxicology – Toxin Reviews
2000- present Member, Editorial Board, Toxicon
2000- 2007 Member, Committee on Seminar Workshop Funding Programme, International Brain Research Organization (IBRO)
1997- 2001 Member, Board of Editors, Philippine Journal of Biotechnology
1999- 2000 Editor in Chief, Philippine Journal of Science

U. S. Patents on Conus peptides: (13 granted)

Patent Titles
- Conotoxins (1984)
- Process & primers for identifying NA encoding A-lineage conotoxin peptides (1996)
- Conotoxin peptides (1997)
- Conotoxin peptides (1997)
- Conotoxin peptide PIIIA (1997)
- Bromo-tryptophan conopeptides (1999)
- Contulakin-G, Analogs thereof and uses therefor (2002)
- Contryphan Peptides ( 2002)
- Contulakin-G, analogs thereof and uses thereof (2002)
- Conantokins (2003)
- Gamma-conopeptides (2003)
- Mu-conopeptides (2004)
- Conotoxins I (2006)

Teaching Activity and Number of advisees who have graduated
Ph. D. Molecular Biology & Biotech., UP Diliman (4)
Ph. D. Chemistry, UP Diliman (1)
Ph. D. Food Technology (Co-adviser), U. P. Diliman (1)
M. S. Biochemistry, UP Manila (16)
B. S. Molecular Biology & Biotech., UP Diliman (~40)
B. S. Chemistry, UP Diliman (1)

Publications:
Dr Lourdes J. Cruz has edited 2 proceedings and published 130 papers

Publication Summary
Biochemistry/Molecular Biology of Conus Neuropeptides - 105
Rice Chemistry/Biochemistry - 5
Nutritional Biochemistry - 2
Metabolism of Pyridine Nucleotides - 3
Biochemistry of Prawns - 2
Other Natural Products & Compounds - 8
Miscellaneous Publications - 5

RICE CHEMISTRY/BIOCHEMISTRY

Bautista, GM, JC Lugay, LJ Cruz, and BO Juliano (1964) Glutamic acid decarboxylase activity as a viability index of artificially dried and stored rice. Cereal Chem. 41:188-191.

Juliano, BO, GB Cagampang, LJ Cruz, and RS Santiago (1964) Some physicochemical properties of rice in Southeast Asia Cereal Chem 41:275-286

Cagampang, GB, LJ Cruz, SG Espiritu, RG Santiago, and BO Juliano (1968) Studies on the extraction and composition of rice proteins Cereal Chem 43:145-155

Cruz, LJ, GB Cagampang, and BO Juliano (1970) Biochemical factors affecting protein accumulation in the rice grain Plant Physiol 46:743-747

Cagampang, GB, LJ Cruz, and BO Juliano (1971) Free amino acids in the bleeding sap and the developing rice grain of the rice plant Cereal Chem 48:533-539

NUTRITIONAL BIOCHEMISTRY

Cruz, LJ, LB Glesne, and CP Berg (1969) Mutual antagonism in the metabolism of D-valine and D-leucine and antagonism by their analogs Arch Biochem Biophys 136:341-349

Cruz, LJ and CP Berg (1970) Incomplete inversion of D-valine and D-leucine Arch Biochem Biophys 138:671-678

METABOLISM OF PYRIDINE NEUCLEOTIDES

Cruz, LJ, JL Salabao, E Flores, and BM Olivera (1975) Pyridine nucleotide metabolism: Purification of a nicotinamide mononucleotide-specific deamidase Kimika 1:40-63

Olivera, BM, MC Rechsteiner, PM Ramos, LJ Cruz and D Hillyard (1980) ADP ribosylation and the pyridine nucleotide cycle In: Novel ADP-Ribosylation of Regulatory Enzymes and Proteins, Smulson and Sugimura (eds), Elsevier North Holland, Inc, pp 85-98

Hillyard, D, M Rechsteiner, PM Ramos, JS Imperial, LJ Cruz, and BM Olivera (1981) The pyridine nucleotide cycle: Studies in Escherichia coli and the human cell line D98/AH2 J Biol Chem 256:8491-8497

BIOCHEMISTRY OF PRAWNS

Coloso, RM and LJ Cruz (1980) Preliminary studies in some aspects of amino acid biosynthesis in juveniles of Peneaus monodon fabricius I Incorporation of 14C from (U-14C)-acetate into amino acids of precipitable proteins Bull Phil Biochem Soc 3:12-22

Coloso, RM and LJ Cruz (1980) Preliminary studies in some aspects of amino acid biosynthesis in juveniles of Peneaus monodon fabricius II Partial purification and characterization of muscle-L-glutamate dehydrogenase Bull Phil Biochem Soc 3:23-37

BIOCHEMISTRY/MOLECULAR BIOLOGY OF CONUS NEUROPEPTIDES

Cruz, LJ, G Corpuz, and BM Olivera (1976) A preliminary study of Conus venom protein Veliger 18:302-308

Cruz, LJ, G Corpuz, and BM Olivera (1977) Mating, spawning, development and feeding habits of Conus geographus in captivity Nautilus 92:150-153

Cruz, LJ (1977) Quantitative assay for Conus toxin Acta Med Phil 13:13-16

Cruz, LJ, WR Gray, and BM Olivera (1978) Purification and properties of a myotoxin from Conus geographus venom Arch Biochem Biophys 190:539-548

Pali, ES, OM Tangco, and LJ Cruz (1979) The venom duct of Conus geographus: Some biochemical and histologic studies Bull Phil Biochem Soc 2:30-51

Gray, WR, A Luque, BM Olivera, J Barrett, and LJ Cruz (1981) Peptide toxins from Conus geographus venom J Biol Chem 256:4734-4740

Clark, C, BM Olivera, and LJ Cruz (1981) A toxin from Conus geographus venom which acts on the vertebrate central nervous system Toxicon 19:691-699

Buenaflor, HG, EMT Mendoza, and LJ Cruz (1981) Studies on the biochemical nature of Conus magus venom Kalikasan 10:220-230

Jimenez, EC and LJ Cruz (1981) Localization of enzymes and proteins in the venom granules of Conus striatus Bull Phil Biochem Soc 4:33-34

McIntosh, M, LJ Cruz, MW Hunkapiller, LE Hood, A Luque, W Gray, and BM Olivera (1982) A peptide toxin from Conus magus venom Arch Biochem Biophys 218:329-334

Jimenez, EC, BM Olivera, and LJ Cruz (1983) Localization of enzymes and possible toxin precursors in granules from Conus striatus venom Toxicon supplement 3:199-202

Reyes, AG and LJ Cruz (1983) Hemolytic activities from Conus textile venom Acta Medica Philippina 19:17-25

Lirazan, MB and Cruz, LJ (1982-83) Biochemical characterization of some toxins from Conus striatus venom Bull Phil Biochem Soc 5,6:15-24 (released April 1985)

Gray, WR, JE Rivier, R Galyean, LJ Cruz, and BM Olivera (1983) Conotoxin M1: Disulfide bonding and conformational states J Biol Chem 258:12247-12251

Gray, WR, TA Luque, R Galyean, E Atherton, RC Sheppard, BL Stone, A Reyes, J Alford, M McIntosh, BM Olivera, LJ Cruz, and J Rivier (1984) Conotoxin GI: Disulfide bridges, synthesis and preparation of iodinated derivatives Biochemistry 23:2796-2802

Olivera, BM, JM McIntosh, LJ Cruz, FA Luque, and WR Gray (1984) Purification and sequence of a presynaptic peptide toxin from Conus geographus venom Biochemistry 23:5087-5090

McIntosh, JM, BM Olivera, LJ Cruz, and WR Gray (1984) gamma-carboxyglutamate in a neuroactive toxin J Biol Chem 259:14343-14346

Olivera, BM, JM McIntosh, C Clark, D Middlemas, WR Gray, and LJ Cruz (1985) A sleep-inducing peptide from Conus geographus venom Toxicon 23:277-282

Cruz, LJ, WR Gray, BM Olivera, RD Zeikus, L Kerr, D Yoshikami, and E Moczydlowski (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels J Biol Chem 260:9280-9288

Olivera, BM, WR Gray, R Zeikus, JM McIntosh, J Varga, J Rivier, V De Santos, and LJ Cruz (1985) Peptide neurotoxins from fish-hunting cone snails Science 230:1338-1343

Cruz, LJ, W Gray, D Yoshikami, and BM Olivera (1985) Conus venoms: A rich source of neuroactive peptides J Toxicology-Toxin Reviews 4:107-132

Gray, WR, DM Middlemas, R Zeikus, BM Olivera, and LJ Cruz (1985) Structure-activity relationships in alpha-conotoxins: A model In: Pep¬tides: Structure and Function, Proc Ninth Amer Peptide Symp, CM Deber, VJ Hruby and KD Kopple, eds, Pierce Chem Co, pp 823-832

Cruz, LJ and BM Olivera (1986) Calcium channel antagonists omega-Conotoxin defines a new high affinity site J Biol Chem 261:6230-6233

Rivier, J, R Galyean, WR Gray, A Azimi-Zonooz, JM McIntosh, LJ Cruz and BM Olivera (1987) Neuronal calcium channel inhibitors Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes J Biol Chem 262:1194-1198

Cruz, LJ, DS Johnson and BM Olivera (1987) A characterization of the omega-conotoxin target Evidence for tissue-specific heterogeneity in Ca channel types Biochemistry 26:820-824

Olivera, BM, LJ Cruz, V de Santos, G LeCheminant, D Griffin, R Zeikus, JM McIntosh, R Galyean, J Varga, WR Gray and J Rivier (1987) Neuronal Ca channel antagonists Discrimination between Ca channel subtypes using omega-conotoxin from Conus magus venom Biochemistry 26:2086-2090

McCleskey, EW, AP Fox, D Feldman, LJ Cruz, BM Olivera, RW Tsien and D Yoshikami (1987) Calcium channel blockade by a peptide from Conus: Specificity and mechanism Proc Nat Acad Sci USA 84:4327-4331

Yeager, RE, D Yoshikami, J Rivier, LJ Cruz and GP Miljanich (1987) Transmitter release from presynaptic terminals of the electric organ: Inhibition by the calcium channel antagonist, omega-Conus toxin J Neuroscience 7:2390-2396

Cruz, LJ, GW LeCheminant and BM Olivera (1987) Biochemical studies of -conotoxin GVIA; A peptide toxin inhibiting voltage-sensitive Ca++ channels In: Integration and Control of Metabolic Processes, Pure and Applied Aspects, OL Kon (ed), ICSU Press, pp 95-102

Cruz, LJ, V de Santos, GC Zafaralla, CA Ramilo, R Zeikus, WR Gray and BM Olivera (1987) Invertebrate vasopressin/oxytocin homo¬logs Characterization of peptides from Conus geographus and Conus striatus venoms J Biol Chem 262:15821-15824

Rivier, J, R Galyean, L Simon, LJ Cruz, BM Olivera and WR Gray (1987) Total synthesis and further characterization of the gamma-carboxy¬glutamate-containing "sleeper" peptide from Conus geographus venom Biochemistry 26:8508-8512

Olivera, BM, WR Gray and LJ Cruz (1988) Marine snail venoms In: Handbook of Natural Toxins, Vol 4, Marine Toxins and Venoms, A Tu (ed), Marcel Dekker, Inc, New York and Basel, pp 327-352

Gray, WR, BM Olivera, LJ Cruz and J Rivier (1988) A model for "sleeper peptide" (conotoxin GV) and other Gla containing molecules In: Peptide Chemistry 1987, T Shiba and S Sakakibara, eds, Protein Research Foundation, Osaka, pp 105-113

Cruz, LJ, DS Johnson, JL Imperial, D Griffin, GL LeCheminant, GP Miljanich and BM Olivera (1988) omega-conotoxins and voltage-sensitive Ca channel subtypes Curr Top Memb Transp 3:417-429

Gray, WR, BM Olivera and LJ Cruz (1988) Peptide toxins from venomous Conus snails Annu Rev Biochem 57:665-700

Johnson, DS, GP Corpuz, and LJ Cruz (1988) omega-Conotoxins as probes for subtypes of neuronal calcium channels In: Protein Structure-Function Relationship, ZH Zaidi (ed), Elsevier Science Publishers BV, pp 67-72

Zafaralla, GC, C Ramilo, WR Gray, R Karlstrom, BM Olivera, and LJ Cruz (1988) Phylogenetic specificity of cholinergic ligands: alpha-Conotoxin SI Biochemistry 27:7102-7105

LeCheminant, GW, AG Reyes, and LJ Cruz (1988) mu-Conotoxin binding: An assay for muscle subtype of voltage-sensitive sodium channels Trans Natl Acad Sci Tech (Philippines) 10:423-439

Cruz, L J and G P Corpuz (1989) mu-Conotoxins: Specific blockers of muscle sodium channel Trans Natl Acad Sci Tech (Philippines) 11:225-232

Hillyard, DR, BM Olivera, S Woodward, GP Corpuz, WR Gray, CA Ramilo and LJ Cruz (1989) A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry 28:358-361

Cruz, LJ, G Kupryszewski, GW LeCheminant, WR Gray, BM Olivera and J Rivier (1989) mu-Conotoxin GIIIA, a peptide ligand for muscle Na channels: Chemical synthesis, radiolabeling and receptor characterization Biochemistry 28:3437-3442

Cruz, LJ (1989) Conotoxins: biochemical probes for ion channels and receptors In: Natural Toxins, Characterization, Pharmacology and Therapeutics, CL Ownby and GV Odell (eds), Pergamon Press, Oxford, pp 66-75

Abogadie, FC, CA, Ramilo, G P Corpuz and LJ Cruz (1990) Biologically active peptides from Conus quercinus, a worm-hunting species Trans Natl Acad Sci Tech (Philippines) 12: 219-232

Olivera, BM, DR Hillyard, J Rivier, S Woodward, WR Gray, G Corpuz, and LJ Cruz (1990) Conotoxins: targeted peptide ligands from snail venoms In: Marine Toxins, S Hall and G Strichartz (eds), American Chemical Society, Washington, DC, pp 246-278

McIntosh, JM, BM Olivera, LJ Cruz, and WR Gray (1984) gamma-carboxyglutamate in a neuroactive toxin J Biol Chem 259:14343-14346

Mena, EE, MF Gullak, MJ Pagnozzi, KE Richter, J Rivier, LJ Cruz and BM Olivera (1990) Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor Neuroscience Letters 118:241-244

Haack, JA, J Rivier, TN Parks, EE Mena, LJ Cruz, and BM Olivera (1990) Conantokin-T; a gamma-carboxyglutamate-containing peptide with N-methyl-D-aspartate antagonist activity J Biol Chem 265:6025-6029

Woodward, SR, LJ Cruz, BM Olivera, and DR Hillyard (1990) Constant and hypervariable regions in conotoxin propeptides EMBO Journal 9:1015-1020

Olivera, BM, J Rivier, C Clark, CA Ramilo, Gloria P Corpuz, Fe C Abogadie, EE Mena, SR Woodward, DR Hillyard, and LJ Cruz (1990) Diversity of Conus neuropeptides Science 249:257-263

Myers, RA, JM McIntosh, J Imperial, RW Williams, T Oas, JA Haack, JF Hernandez, J Rivier, LJ Cruz and BM Olivera (1990) Peptides from Conus venoms which affect Ca++ entry into neurons J Toxicol-Toxin Reviews 9:179-202

Mena, EE, MF Gullak, MJ Pagnozzi, KE Richter, J Rivier, LJ Cruz and BM Olivera (1990) Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor Neuroscience Letters 118:241-244

Olivera, B M, R Rivier, J K Scott, D R Hillyard, L J Cruz (1991) Conotoxins J Biol Chem 266: 22067-22070

Olivera, B M, J S Imperial, L J Cruz, V P Bindokas, V J Venema, and M E Adams (1991) Calcium channel-targeted polypeptide toxins Annl N Y Acad Sci 635: 114-122

Myers, R A, G C Zafaralla, W R Gray, J Abbott, L J Cruz, and B M Olivera (1991) alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors Biochemistry 30: 9370-9377

Hillyard, D R, V D Monje, I M Mintz, B PBean, L Nadasdi, J Ramachandran, G Miljanich, A Azimi-Zonooz, J M McIntosh, LJ Cruz, J S Imperial, and B M Olivera (1992) A new Conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron 9: 69-77

Cruz, L J, C A Ramilo, G P Corpuz, and B M Olivera (1992) Conus Peptides: Phylogenetic Range of Biological Activity Biol Bull 183: 159-164

Olivera, B M, D S Johnson, A Azimi-Zonooz, and L J Cruz (1992) Peptides in the venom of the geography cone, Conus geographus In: Toxins and Targets, D Waters, M Lavin, D Maguire, and J Pearn (eds), Harwood Academic Publ, Melbourne, Australia, pp 19-28

Olivera, B M, L J Cruz, R A, Myers, D R Hillyard, J Rivier, and J K Scott (1992) Conus peptides and biotechnology In: Neurotox '91, Molecular Basis of Drug & Pesticide Action, I R Duce (eds), Elsevier Applied Science, London, U K, pp 45-55

Ramilo, C A, G C Zafaralla, L Nadazdi, G Miljanich, J Ramachandran, B M Olivera, and L J Cruz (1992) Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry 31: 9919-9926

Cruz, L J, G P Corpuz, C A Ramilo, G Zafaralla, B Johnson, T Leitner, D Yoshikami, and B M Olivera (1992) The biological role and pharmacological uses of conotoxins In: Proc 7th Asian Symposium on Medicinal Plants, Spices, & Other Natural Products, L J Cruz, G P Concepcion, A S Mendigo, and B Q Guevara (eds), ASOMPS VII Organizing Committee, Manila, Philippines, pp 90-97

Olivera, BM, J imperial, J Hunsperger, C Colledge, RA Myers, AD Santos, VD Monje, LJ Cruz, and DR Hillyard (1992) Conus peptides, a pharmacologically diverse class of marine natural products In: Proc 7th Asian Symposium on Medicinal Plants, Spices, & Other Natural Products, L J Cruz, G P Concepcion, A S Mendigo, and B Q Guevara (eds), ASOMPS VII Organizing Committee, Manila, Philippines, pp 19-29

Olivera, BM, JM McIntosh and LJ Cruz (1993) Conus peptides as tools for the neuroscientist In: Gene-Brain-Behaviour, Proceedings of the 12th Gottingen Neurobiology Conference, N Elsner and M Heisenberg (eds) George Thieme Verlag, Stuttgart, Germany, pp 159-169

Myers, RA, LJ Cruz, JE Rivier and BM Olivera (1993) Conus peptides as chemical probes for receptors and ion channels Chem Rev 93:1923-1936

Cruz LJ and BM Olivera (1993) Conus venom neuropeptides Neuroscience Year: Suppl 3 to the Encyclopedia of Neuroscience B Smith and G Addleman (ed),Birkhaüser, Boston, pp 32-33

Cruz LJ (1993) Potential Drugs from Deadly Marine Snails IFS VII General Assembly (Proceedings), International Foundation for Science, Stockholm, Sweden, pp 16-20

Torres, JL, E Mahe, J-F Hernandez, C Miller, LJ Cruz, BM Olivera and JE Rivier (1994) In vivo activities of conantokin-G analogs Peptides: Chemistry, Structure and Biology, R S Hodges and J A Smith (eds), Escom, Leiden pp 526-528

Shon, K-J, Hasson A, Spira ME, Cruz LJ, Gray WR and Olivera BM (1994) -Conotoxin GmVIA, a Novel Peptide from the Venom of Conus gloriamaris Biochemistry, 33:11420-11425

Cruz LJ and White J (1995) Clinical Toxicology of Conus Snail Stings In: Clinical Toxicology of Animal Venoms (Meier, J, White, J, Eds) p117-127 Boca Raton, FL: CRC Press

Hopkins C, Grilley M, Miller C, Shon KJ, Cruz LJ, Gray, W R, Dykert, J, Rivier, J, Yoshikami, D and Olivera, B M (1995) A new family of Conus peptides targeted to the nACh receptor J Biol Chem, 270: 22361-22367

Newcomb, R, Gaur, S, Bell, J K, and Cruz, L J (1995) Structural and Biosynthetic Properties of Peptides in Cone Snail Venoms Peptides 16: 1007-1017

Cruz, L J (1995) Molecular strategies for discovery of peptides in Conus venom Proc Symp on Molecular Approaches in Biology, Japan Society for the Promotion of Science-Department of Science and Technology, University of the Philippines Diliman, pp 17-23

Monje V D, Cruz, L J, Ward, R H, and Olivera B M (1995) Molecular Phylogeny of Conus Proc Symp on Molecular Approaches in Biology, Japan Society for the Promotion of Science-Department of Science and Technology, University of the Philippines Diliman, pp 92-103

Santos, A D, Cruz, L J, Hillyard, D R, and Olivera, B M (1995) Cloning conotoxin cDNA using a modified plasmid vector Proc Symp on Molecular Approaches in Biology, Japan Society for the Promotion of Science-Department of Science and Technology, University of the Philippines Diliman, pp 104-108

Jimenez, E C, Olivera, B M, Gray, W R, and Cruz, L J (1996) Contryphan is a D-tryptophan-containing Conus peptide J Biol Chem 271: 28002-28005

Cruz, L J, Ramilo, C A & Corpuz, G P (1996) Neuropeptides of dangerous Conus species In: Towards Rational Drug Therapy at the Turn of the Century, Proceedings 1995 SEA/WP Regional Metting of Pharmagologists, pp 264-270 Manila, Phil Soc Exptl Clinical Pharmacol

Jimenez, EC, Olivera, BM, Gray, WR and Cruz, LJ (1997) Contryphan is a D- typtophan-containing Conus peptide J Biol Chem271:28002-28005

Jimenez, E C, Craig, A Grey, Watkins, M, Hillyard, D R, Gray, W R, Gulyas, J, Rivier, Cruz, L J, and Olivera, B M ( 1997) Bromocontryphan: Post translational bromination of tryptophan Biochemistry 36: 989-994

Craig, A G, Jimenez, E C, Dykert, J, Nielsen, D B, Gulyas, J, Abogadie, F C, Porter, J, Rivier, J S, Cruz, L J, Olivera, B M, and McIntosh, J M (1997) A novel post-translational modification involving bromination of tryptophan J Biol Chem 272: 4689-4698

Cruz, L J mu-Conotoxins (Conus geographus) in Guidebook to Protein Toxins and Their Use in Cell Biology, R Rappuoli & Cesare Montecucco, Editors, Oxford University Press, Oxford, 1997

Jacobsen, R, Jimenez, EC, Grilley, M, McW ins, M, Hillyard, D, Cruz, LJ, and Olivera BM (1998) The contryphans, a D-tryptophan – containing family of Conus peptides: Interconversion between conformers J Peptide Res 51:173-179

Craig, AG, Zafaralla, G, Cruz, LJ, Santos, AD, Hillyard, D, Dykert, J, Rivier, JE, Gray, WR, Imperial, J, DelaCruz R, Sporning A, Terlan, H, West, R, Yoshikami, D, and Olivera BM (1998) An O-glycosylated neuroexcitatory Conus peptide Biochemistry 37:16019-16025

Shon, KJ, Olivera, B M, Watkins, D, Jacobsen, R B Gray, W R, Floresca, C Z, Cruz, L J, Hillyard, D R, Brink, A, Terlau, H, and Yoshikami, D (1998)) mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes J Neurosci18:4473-4481

McIntosh, J M, Olivera, B M, and Cruz, L J (1999) Conus peptides as probes in ion channels Methods Enzymol 294: 605-624

Craig, A G, Norberg, T, Griffin, D, Hoeger, C, Akhtar, M, Schimidt, K, Low, W, Dykert, J, Richelson, E, Navarro, V, Mazella, J, Watkins, M, Hillyard, D, Imperial, J, Cruz, L J and Olivera, B M (1999) Contulakin, an O-glycosylated Conus peptide J Biol Chem 274: 13752-13759

Jacobsen, R B, Jimenez, E C, de la Cruz, Gray, W R, Cruz, L J and Olivera B M (1999) A novel D-leucine-containing Conus peptide: diverse conformational dynamics in the contryphan family J Peptide Res 54: 93-99

Walker, C, Steel, D, Jacobsen, R B, Lirazan M B, Cruz L J, Hooper D, Shetty, R, dela Cruz, R C, Nielsen, J S, Zhou, L M, Bandyopadhyay, P, Craig, A G and Olivera B M (1999) The T-superfamily of conotoxins J Biol Chem 274: 30664-30671

Walker, C, Steel, D, Jacobsen, R B, Lirazan M B, Cruz L J, Hooper D, Shetty, R, dela Cruz, R C, Nielsen, J S, Zhou, L M, Bandyopadhyay, P, Craig, A G and Olivera B M (1999) The T-superfamily of conotoxins J Biol Chem 274: 30664-30671

Monje, V D, Ward, R, Olivera, B M and Cruz, L J (1999) 16S Mitochondrial RNA Sequences: A comparison of seven Conus species Philippine J Sci 128: 225-237

Lirazan, M B, Braig, A G, Shetty, R, Walker, C S, Olivera, B M and Cruz, L J (1999) Multiple bromotryptophan and gamma-carboxyglutamate residues in a Conus peptide Philippine J Sci 128: 239-246

Olivera, B M, Cruz, L J and Yoshikami, D (1999) Effects of Conus peptides on the behavior of mice Current Opinions Neurobiol 9: 772-777

White, H S, McCabe, R T, Armstrong, H, Donevan, S, Cruz, L J, Abogadie, F C, Torres, J, Rivier, J E, Paarman, I, Hollmann, M and Olivera, B M (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus J Pharmacol Exptl Therapeutics 292: 425 – 432

Cruz, L J, McIntosh, J M, Imperial, J S, and Gray W R (2000) Conus Peptides and their iodinated derivatives as probes for ion channels and receptors Methods and Tools in Biosciences and Medicine: Animal Toxins, H Rochat and M-F Martin-Eauclaire, Eds, Birkhauser Verlag, Basel, pp 74 – 89

Lirazan, M B, Hooper, D, Corpuz, G P, Ramilo, C A, Banyopadhyay, P, Cruz, L J, and Olivera, B M (2000) The Spasmodic peptide defines a new conotoxin family Biochemistry 39: 1583 – 1588

McIntosh, J M, Corpuz, G P, Layer, R T, Garrett, J E, Wagstaff, J D, Bulaj, G, Vyazovkina, A, Yoshikami, D, Cruz, L J, and Olivera, B M (2000) Isolation and characterization of a novel Conus peptide with apparent antinociceptive activity, J Biol Chem 275: 32391-32397

Olivera, BM and Cruz, L J (2001) Conotoxins, in retrospect Toxicon 39: 7-14

Jimenez EC, Watkins M, Juszczak LJ, Cruz LJ, and Olivera BM (2001) Contryphans from Conus textile venom ducts Toxicon 39:803-808

Espiritu, D J D, Watkins, M, Dia-Monje, V, Cartier, E, Cruz, L J, and Olivera, B M (2001) Venomous cone snails: molecular phylogeny and the generation of toxin diversity Toxicon 39: 1899-1916

Lirazan, M, Jimenez, E C, Grey Craig, A, Olivera, B M and Cruz, L J (2002) Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family Toxicon 40: 901-8

Jimenez, E C, Donevan, S, Walker, C, Zhou, L-M, Nielsen, J, Cruz, L J, Armstrong, H, White, H S and Olivera B M (2002) Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency Epilepsy Research 51: 73-80

Espiritu, J D, Cruz, L J, Cartier, G E and Olivera, BM (2002) Venomous Gastropods: Conus, conoideans and other neogastropod families Supplement 4, Systematics, Phylogeny and Biology of the Neograstropoda, 3rd International Workshop on Malacology Bolletino Malacologico 38: 147-160

Jimenez EC, Shetty RP, Lirazan M, Rivier J, Walker C, Abogadie FC, Yoshikami D, Cruz LJ, Olivera BM 2003 Novel excitatory Conus peptides define a new conotoxin superfamily J Neurochem 85:610-21

Imperial JS, Watkins M, Chen P, Hillyard DR, Cruz LJ, Olivera BM 2003 The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata Toxicon 42:391-8

Santos AD, McIntosh JM, Hillyard DR, Cruz LJ, Olivera BM 2004 The A-superfamily of conotoxins: Structural and functional divergence J Biol Chem 279:17596-17606

Cruz LJ and Jimenez LC 2004 Conus venom neuropeptides Encyclopedia of Neuroscience, G Adelman and BH Smith, editors, 3rd edition, Elsevier (Electronic publication, available only as CD)

Corpuz GP, Jacobsen RB, Jimenez EC, Watkins M, Walker C, Colledge C, Garrett JE, McDougal O, Li W, Gray WR, Hillyard DR, Rivier J, McIntosh JM, Cruz LJ, Olivera BM 2005 Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186

OTHER NATURAL PRODUCTS AND COMPOUNDS

Nacino FM, Barretto CB, and Cruz LJ (1975) The effect of citrus oil on tumor production by DMBA Kalikasan 4:240-247

Cruz LJ (1996) Some biosafety concerns: Physical containment for an avirulent strain of Mycobacterium tuberculosis Bull Phil Soc Biochem Mol Biol 15: 7-9

Ontengco DC, Isaac CA, Talaue M, Cruz, LJ (1997) Correlating the Alamar Blue assay and the agar dilution method for MIC determination of anti-tuberculars Phil J Med Tech 1: 43-46

Mangalindan GC, Talaue MT, Cruz LJ, Franzblau SG, Adams LB, Richardson AD, Ireland CM, Concepcion GP (2000) Agelasine F from a Philippine Agelas sp sponge exhibits in vitro antituberculosis activity Planta Med 66: 1 – 2

Davis RA, Mangalindan GC, Bojo ZP, Antemano RR, Rodriguez NO, Concepcion GP, Samson SC, de Guzman D, Cruz LJ, Tasdemir D, Harper MK, Feng X, Carter GT, Ireland CM. 2004. Microcionamides A and B, bioactive peptides from the Philippine sponge Clathria (Thalysias) abietina J Org Chem 69:4170-4176

De Leon MLA, Chua MT, Endoma-Arias MAA, Concepcion GP, Cruz, LJ (2006) A modified procedure for the preparation of mitoxantrone. Phil. J. Science 135: 83-92.

Tiburcio PC, Galvez FCF, Cruz LJ, Gavino VC (2007) Optimization of low-cost drying methods to minimize lipid peroxidation in Spirulina platensis grown in the Philippines. J. Appl. Phycol. 19:719–726.

Tiburcio PC, Galvez FCF, Cruz LJ, Gavino VC (2007) Determination of shelf life of Spirulina platensis (MI2) grown in the Philippines. J. Appl. Phycol. 19:727–731.

RECENT MISCELLANEOUS PUBLICATIONS:

Azanza RV, dela Roza A, Sombrito EZ, Cruz LJ, Siringan FP, McGlone MSD, Jacinto GS, Villanoy CL and Duyanen J. 2003. Harmful algal bloom (HAB) management lessons from a multidisciplinary research program in Manila Bay, Philippines. In: Recent Advances in the Prevention and Management of Harmful Algal Blooms in the South China Sea, KC Ho, SH Lu, TS Yu & KF Wong (eds.), The Association on Harmful Algal Blooms in the South China Sea, Hong Kong pp. 59-61

Cruz LJ. 2005. Natural products research and bioprospecting. In PES: Sustainable Financing for Conservation and Development: Proc National Conference-Workshop on Payments for Environmental Services: Direct Incentives for Biodiversity Conservation and Poverty Alleviation, Manila, 1-2 March 2005, JE Padilla, E Tongson, R Lasco (eds.), WWF, ICRAF, REECS, UP-CIDS, UPLB-ENFOR, CARE, pp. 116-125.

Cruz LJ. 2005. Scientific Research, Biodiversity and Bioprospecting. In: Indigenous Peoples and the Convention on Biological Diversity. Proc. Asia-Regional Capacity Building Workshop on the Implementation of the CBD, Baguio City, 25-27 April 2005, J Cariño (Team Leader), Capacity Building and Advocacy Series no. 1: The Philippine Report, Tebtebba Foundation, Baguio City.

Motin BB, Cruz LJ, Gifford F, Kron, MA. 2006. A modified Socio-Cultural Development Index (SCDI) for the Aytas of Kanawan, Morong, Bataan, Philippines. Indigenous Perspectives (Journal of Tebtebba, Indigenous Peoples’ International Centre for Policy Research & Education), 8 (1): 51-71.

Motin BB, Salonga, J, Cruz LJ. 2008. An index to assess the impact of development interventions on the community of Kanawan Aytas. In Resource Book, International Indigenous Forum on Biodiversity (IIFB) Working Group on Indicators, In press.
 
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