Nanotechnology may provide new strategies for regenerative medicine, including better tools to improve or restore damaged tissues, according to a review paper by Taiwanese researchers
Published in the journal Science and Technology of Advanced Materials, the paper summarizes the current state of knowledge on nanotechnology with application to stem cell biology. (The term “nanotechnology” refers to the design, construction, generation and use of nanoscale (1-100 nm) structures or materials.)
|Summary figure. Nanotechnology regulates stem cell function. (A) Suitable spacing for integrin activation and integrin-mediated cell adhesion, cytoskeleton organization and cell spreading. (B) Modified nanoscaffolds regulate stem cell self-renewal, neural differentiation and osteogenic differentiation.
|Copyright : CC-BY Yang-Kao Wang, 2013
Stem cells are considered an important potential source for repairing damaged human tissues. Researchers have found that the adhesion, growth, and differentiation of stem cells are likely controlled by their surrounding microenvironment, which contains both chemical and physical cues. These cues include the “nanotopography” of the complex extracellular matrix or architecture that forms a network for human tissues.
In their review paper, Yang-Kao Wang and colleagues describe studies showing how this nanotopography (which includes nanosized pores, grooves, ridges, etc.) plays important roles in the behaviour and fate of stem cells. The authors also discuss the application of nanoparticles to stem cell isolation, tracking and imaging; how to translate nanotechnology from two to three dimensions; and the potential limitations of using nanomaterials in stem cell biology.
The paper concludes that “understanding [the] interactions of nanomaterials with stem cells may provide knowledge applicable to [the development of improved] cell-scaffold combinations in tissue engineering and regenerative medicine.”
For more information about this paper, please contact:
GIBMTE, Taipei Medical University
250 Wuxing St., Xinyi Dist.
Taipei City 110, Taiwan
Phone:886-2-27361661, ext 5200
National Institute for Materials Science, Tsukuba, Japan
Nanotechnology in the regulation of stem cell behavior. Sci Technol Adv Mater Vol. 14 (2013) p. 054401 DOI: http://dx.doi.org/10.1088/1468-6996/14/5/054401