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Article Released Sun-18th-February-2007 20:35 GMT
Contact: Ruth Institution: Nature Publishing Group
 A method to regrow teeth

Scientists have for the first time successfully replaced natural teeth in mice with teeth that were created in a Petri dish from single cells. The experiment is described online this week in Nature Methods.


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A method to regrow teeth – Nature Methods

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********************** NATURE METHODS ******************

[10] A method to regrow teeth
DOI: 10.1038/nmeth1012

Scientists have for the first time successfully replaced natural teeth in mice with teeth that were created in a Petri dish from single cells. The experiment is described online this week in Nature Methods.

Takashi Tsuji and colleagues started with the two cell types that develop into a tooth –mesenchymal and epithelial cells. First they grew each cell type separately to get larger quantities of cells and then injected them into a drop of collagen – a substance which ‘glues’ cells together in an organism. The cells developed into a budding tooth with high efficiency, and when transplanted into the cavity of an extracted tooth in a mouse developed normally and showed the same composition and structure as natural teeth.

The authors provide further evidence that this method can be applied to any organ that develops from these cell types by regrowing a follicle that eventually forms a whisker in a mouse.

Author contact:

Takashi Tsuji (Tokyo University of Science, Chiba, Japan)
Tel: +81 4 7122 9711; E-mail:

Other papers from Nature Methods to be published online at the same time and with the same embargo:

[11] Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology
DOI: 10.1038/nmeth1007


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Keywords associated to this article: teeth
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